Volume 30, Issue 2 (Dec 2011)                   jame 2011, 30(2): 1-12 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

M.H. Fathi, A. Hanifi, S.I. Roohani Esfahani. Synthesis, characterization, and comparative bioactivity evaluation of nano structured hydroxyapatite. jame. 2011; 30 (2) :1-12
URL: http://jame.iut.ac.ir/article-1-524-en.html
Biomaterials Research Group, Department of Materials Engineering, Isfahan University of Technology
Abstract:   (8516 Views)
Due to its biocompatibility, bioactivity and high durability properties, hydroxyapatite (HA) has a wide range of applications in medical cases such as bone defect treatment and bone tissue regeneration. Biological apatite as the most important integrity of the mineral part of hard tissues consists of tiny hydroxyapatite crystals in nanoregime. It seems that using the artificial hydroxyapatite with similar structure and chemical composition to biological apatite could increase its durability inside the natural hard tissues. The aim of the present work was the synthesis of nano structured hydroxyapatite via different routes, comparison of their characterization and enhancement of the bioactivity and bioresorbability of prepared hydroxyapatite by controlling its crystal size and chemical composition. Nano structured hydroxyapatite was prepared by mechanical activation and sol-gel routes. X-ray diffraction technique (XRD), Fourier transform infra red spectroscopy (FTIR) and transmission electron microscopy (TEM) were used to characterize the prepared hydroxyapatite powders. The synthesized powder was soaked in simulated body fluid (SBF) for various periods of time in order to evaluate its bioresorbability and bioactivity after immersion in SBF. Atomic absorption spectroscopy (AAS) was used to determine the dissolution rate of calcium ions in SBF media. Results showed that the mechanical activation prepared HA powder had nano scale structure with mean size of 29 nm and the sol gel prepared HA powder had nano scale structure with mean size of 25 nm. Ionic dissolution rate of prepared nano structured powders was higher than the conventional HA (with micron size) and were similar to biological apatite. It could be concluded that bioactivity behavior of hydroxyapatite powder is affected by its crystalline size. By using the nano structure HA powder with less than 50 nm crystalline size, the optimum bioactivity and bioresorbability would be achieved.
Full-Text [PDF 878 kb]   (3766 Downloads)    
Type of Study: Research | Subject: General
Received: 2015/02/9 | Accepted: 2015/05/5 | Published: 2015/05/5

Add your comments about this article : Your username or Email:
CAPTCHA

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2021 CC BY-NC 4.0 | Journal of Advanced Materials in Engineering (Esteghlal)

Designed & Developed by : Yektaweb