Fabrication of Chitosan/Poly (vinyl alcohol)/Carbon Nanotube/Bioactive Glass Nanocomposite Scaffolds for Neural Tissue Engineering

Authors

1 1- Department of Materials Engineering, Faculty of Engineering, University of Shahrekord, Shahrekord, Iran

2 2- Department of Biology, Faculty of Science, University of Isfahan, Isfahan, Iran

Abstract

The aim of this study was to fabricate carbon nanotube (CNT) and bioactive glass nanoparticles (BG) (at levels of
5 and 10 wt%) incorporated electrospun chitosan (CS)/polyvinyl alcohol (PVA) nanofibers for potential neural tissue engineering applications.The morphology, structure, and mechanical properties of the formed electrospun fibrous mats were characterized using scanning electron microscopy (SEM) and mechanical testing, respectively. In vitro cell culture of embryonal carcinoma stem cells (P19) were seeded onto the electrospun scaffolds. The results showed that the incorporation of CNTs and BG nanoparticles did not appreciably affect the morphology of the CS/PVA nanofibers. The maximum tensile strength (7.9 MPa) was observed in the composite sample with 5 %wt bioactive glass nanoparticles. The results suggest that BG and CNT-incorporated CS/PVA nanofibrous scaffolds with small diameters, high porosity, and promoted mechanical properties can potentially provide many possibilities for applications in the fields of neural tissue engineering and regenerative medicine.

Keywords

References

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Journal of Advanced Materials in Engineering (Esteghlal)
Volume 35, Issue 1
June 2016
Pages 35-46

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