Adsorption of Fluconazole Drug on Silica Aerogel‌ by Immersion Method and Investigation of the Rate and Mechanism of Drug Release

Authors

Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran.

Abstract

In this study, adsorption of fluconazole on silica aerogel was performed successfully by the immersion method in the 1% solution of fluconazole-ethanol at the ambient condition and without using the supercritical method. The hydrophobic and hydrophilic silica aerogels were synthesized by the two-stage sol-gel method and dried at the ambient temperature. This method had most of drug loading at 24 h. It was 1.92% and 1.98% for the hydrophilic and hydrophobic silica aerogels, respectively. Physical properties of the synthesized aerogels were studied by the nitrogen absorption and desorption tests. The presence of fluconazole and the chemical structure of the samples were determined by fourier-transform infrared spectroscopy (FTIR). As well, the loading and release of the drug were investigated using a spectrophotometer. The results showed the structure of the synthesized aerogels had a pore diameter of 6-8 nm and a surface area of about 800-100 m2/g. The study of the drug release also revealed that the release rate of fluconazole in the hydrophilic silica aerogel was higher than that of the hydrophobic sample.

Keywords

References

1. Siepmann, J., Siegel, R. A., and Rathbone, M. J., Fundamentals and Applications of Controlled Release Drug Delivery, Springer, New York, 2012.‌
2. Arruebo, M., “Drug Delivery from Structured Porous Inorganic Materials”, Wiley Interdisciplinary Reviews: Nanomedicine and Nanobiotechnology, Vol. 4, pp. 16-30, 2012.
3. Davis, M. E., “Ordered Porous Materials for Emerging Applications”, Nature, Vol. 417, pp. 813-821, 2002.‌
4. Pekala, R. W., and Alviso, C. T. “A New Synthetic Route to Organic Aerogels”, MRS Online Proceedings Library Archive, Vol. 180, 1990.
5. Graf, C., Dembski, S., Hofmann, A., and Rühl, E., “A General Method for the Controlled Embedding of Nanoparticles in Silica Colloids”, Langmuir, Vol. 22, pp. 5604-5610, 2006.
6. Radin, S., El-Bassyouni, G., Vresilovic, E. J., Schepers, E., and Ducheyne, P., “In Vivo Tissue Response to Resorbable Silica Xerogels as Controlled-Release Materials”, Biomaterials, Vol. 26, pp. 1043-1052, 2005.
7. Afrashi, M., Semnani, D., Talebi, Z., Dehghan, P., and Maherolnaghsh, M., “Comparing the Drug Loading and Release of Silica Aerogel and PVA Nano Fibers”, Ournal of Non-Crystalline Solids, Vol. 503, pp. 186-193, 2019.
8. Schwertfeger, F., Zimmermann, A., and Krempel, H., Use of Inorganic Aerogels in Pharmacy, Google Patents No. 6,280,744. Washington, DC, 2001.
9. Smirnova, I., Suttiruengwong, S., Seiler, M., and Arlt, W., “Technology, Dissolution Rate Enhancement by Adsorption of Poorly Soluble Drugs on Hydrophilic Silica Aerogels”, Pharmaceutical Development and Technology, Vol. 9, pp. 443-452, 2005.
10. Guenther, U., Smirnova, I., and Neubert, R. H. H., “Biopharmaceutics, Hydrophilic Silica Aerogels as Dermal Drug Delivery Systems–Dithranol as a Model Drug”, European Journal of Pharmaceutics and Biopharmaceutics, Vol. 69, pp. 935-942, 2008.
11. Aegerter, M. A., Leventis, N., and Koebel, M. M., Advances in Sol-Gel Derived Materials and Technologies, Springer, New York, USA, 2011.
12. Ulker, Z., and Erkey, C. “An Advantageous Technique to Load Drugs Into Aerogels: Gas Antisolvent Crystallization Inside the Pores”, The Journal of Supercritical Fluids, Vol. 120, pp. 310-319, 2017.
13. Latifi, F., Talebi, Z., Khalili, H., and Zarrebini, M., “Effect of Processing Parameters and Pore Structure of Nanostructured Silica Aerogel on the Physical Properties of Aerogel Blankets”, Materials Research Express, Vol. 5, 2018, DOI: 10.1088/2053-1591/aac1e2.
14. Mazraeh-shahi, Z. T., Shoushtari, A. M., Abdouss, M., and Bahramian, A. R., “Relationship Analysis of Processing Parameters with Micro and Macro Structure of Silica Aerogel Dried at Ambient Pressure”, Journal of Non-Crystalline Solids, Vol. 376, pp. 30-37, 2013.
15. Semnani, D., Afrashi, M., Alihosseini, F., Dehghan, P., and Maherolnaghsh, M., “Investigating the Performance of Drug Delivery System of Fluconazole Made of Nano-Micro Fibers Coated on Cotton/Polyester Fabric”, Journal of Materials Science: Materials in Medicine, Vol. 28, pp. ???, 2017.
16. Alkhamis, K. A., Obaidat, A. A., and Nuseirat, A. F., “Solid-State Characterization of Fluconazole”, Pharmaceutical Development and Technology, Vol. 7, pp. 491-503, 2002.
17. Salerno, C., Carlucci, A. M., Chiappetta, D. A., and Bregni, C., “Inhibition of Fluconazole In Vitro Antifungal Activity in Formulations Containing Propylene Glycol”, Latin American Journal of Pharmacy, Vol. 30, pp. 1406-1413, 2011.
18. Qin, Q., and Ye, J., (Eds.), Toughening Mechanisms in Composite Materials, Elsevier, 2015.
19. Azaïs, T., Tourné-Péteilh, C., Aussenac, F., Baccile, N., Coelho, C., Devoisselle, J. M., and Babonneau, F., “Solid-State NMR Study of Ibuprofen Confined in MCM-41 Material”, Chemistry of Materials, Vol. 18, pp. 6382-6390, 2006.
20. Wang, X., Ben Ahmed, N., Alvarez, G. S., Tuttolomondo, M. V., Hélary, C., Desimone, M. F., and Coradin, T., “Sol-Gel Encapsulation of Biomolecules and Cells for Medicinal Applications”, Current Topics in Medicinal Chemistry, Vol. 15, pp. 223-244, 2015.
21. Fan, J., Yu, C., Gao, F., Lei, J., Tian, B., Wang, L., and Zhao, D., “Cubic Mesoporous Silica with Large Controllable Entrance Sizes and Advanced Adsorption Properties”, Angewandte Chemie International Edition, Vol. 42, pp. 3146-3150, 2003.
22. Stergar, J., and Maver, U. “Review of Aerogel-Based Materials in Biomedical Applications”, Journal of Sol-Gel Science and Technology, Vol. 77, pp. 738-752, 2016.
23. Lovskaya, D. D., Lebedev, A. E., and Menshutina, N. V., “Aerogels as Drug Delivery Systems: In Vitro and in Vivo Evaluations”, The Journal of Supercritical Fluids, Vol. 106, pp. 115-121, 2015.
24. Vallet-Regi, M., Doadrio, J. C., Doadrio, A. L., Izquierdo-Barba, I., and Pérez-Pariente, J., “Hexagonal Ordered Mesoporous Material as a Matrix for the Controlled Release of Amoxicillin”, Solid State Ionics, Vol. 172, pp. 435-439, 2004.
Journal of Advanced Materials in Engineering (Esteghlal)
Volume 38, Issue 2
September 2019
Pages 25-34

Files

Share

How to cite

Statistics

تحت نظارت وف ایرانی