SYNTHESIS AND EVALUATION OF MECHANICAL AND BIOACTIVE PROPERTIES OF β-TCP/ BREDIGITE SCAFFOLD FOR BONE TISSUE ENGINEERING APPLICATIONS

Authors

1 Department of Materials Engineering, Faculty of Materials and Industries Engineering, Noshirvani University of Technology, Babol.

2 Department of Materials Engineering, Faculty of Materials Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Iran.

Abstract

Development of bioactive ceramic composite scaffold materials with enhanced mechanical strength has been a topic of great interest in bone tissue engineering. In the present study, β-tricalcium phosphate scaffolds with various amounts of bredigite and an interconnected pore network suitable for bone regeneration were fabricated by the space holder method. The effect of high concentrations of bredigite on the structure, mechanical properties (compressive strength), and in vitro bioactivity was investigated. According to the results, immersion in simulated body fluid (SBF) led to the apatite formation on the surface of the scaffold, but increasing the bredigite content caused the agglomeration of the bredigite phase at the grain boundaries and deteriorated the mechanical properties.

Keywords

References

1. Niaza, K. V., Senatov, F. S., Kaloshkin, S. D., Maksimkin, A. V., and Chukov, D. I., “3D-Printed Scaffolds Based on PLA/HA Nanocomposites for Trabecular Bone Reconstruction”, Journal of Physics: Conference Series, Vol. 741, pp. 28-30, 2016.
2. Tabata, Y., “Recent Progress in Tissue Engineering”, Drug Discovery Today, Vol. 6, pp. 483-487, 2001.
3. Mikos, A. G., and Temenoff, J. S., “Formation of Highly Porous Biodegradable Scaffolds for Tissue Engineering”, Electronic Journal of Biotechnology, Vol. 3, pp. 23-24, 2000.
4. Derakhshanfar, S., Mbeleck, R., Xu, K., Zhang X., Zhong, W., and Xing, M., “3D Bioprinting for Biomedical Devices and Tissue Engineering: A Review of Recent Trends and Advances”, Bioactive Materials, Vol. 3, pp.144-156, 2018.
5. Karageorgiou, V., and Kaplan, D., “Porosity of 3D Biomaterial Scaffolds and Osteogenesis”, Biomaterials, Vol. 26, pp. 5474-91, 2005.
6. Tanodekaew, S., Channasanon, S., Kaewkong, P., and Uppanan, P., “PLA-HA Scaffolds: Preparation and Bioactivity”, Procedia Engineering, Vol. 59, pp. 144-149, 2013.
7. Nalla, R. K., Kinney, J. H., and Ritchie, R., “Mechanistic Fracture Criteria for Failure of Human Cortical Bone”, Nature Materials, Vol. 2, pp. 164-169, 2003.
8. Asa’ad, F., Pagni, G., Pilipchuk, S. P., Gianni, A. B., Giannobile, W. V., and Rasperini, G., “3D-Printed Scaffolds and Biomaterials: Review of Alveolar Bone Augmentation and Periodontal Regeneration Applications”, International Journal of Dentistry, Vol. 2016, pp. 1-16, 2016.
9. Mirhadi, B., Mehdikhani, B., and Askari, N., “Synthesis of Nano-Sized β-Tricalcium Phosphate via Wet Precipitation”, Processing and Application of Ceramics, Vol. 5, pp. 193-198, 2011.
10. Salehi, S., and Fathi, M. H., “Fabrication and Characterization of Sol-Gel Derived Hydroxyapatite/Zirconia Composite Nanopowders with Various Yttria Contents”, Ceramics International, Vol. 36, pp. 1659-1667, 2010.
11. Mirhadi, S. M., Tavangarian, F., and Emadi, R., “Synthesis, Characterization and Formation Mechanism of Single-phase Nanostructure Bredigite Powder”, Materials Science and Engineering C, Vol. 32, pp.133-139, 2012.
12. Shi, J., Votruba, A. R., Farokhzad, O. C., and Langer, R., “Nanotechnology in Drug Delivery and Tissue Engineering: from Discovery to Applications”, Nano Letters, Vol. 10, pp. 3223-3230, 2010.
13. Ghomi, H., Emadi, R., and Haghjooye Javanmard, Sh., “Fabrication and Characterization of Nanostructure Diopside Scaffolds Using the Space Holder Method: Effect of Different Space Holders and Compaction Pressures”, Materials & Design, Vol. 91, pp. 193-200, 2016.
14. Lopes, J. H., Magalha, J. A., Gouveia, R. F., Bertran, C. A., Motisuke, M., Camargo, S., and Triche, E., “Hierarchical Structuresof β-TCP/45S5 Bioglasshybrid Scaffolds Preparedbygelcasting”, Journal of the mechanical behavior of biomedical materials, Vol. 62, pp. 10-23, 2016.
15. Bakhsheshi-Rad, H. R, Hamzah, E., Abbasizadeh, N., Najafinezhad, A., and Kashefian, M., “Synthesis of Novel Nanostructured Bredigite–Amoxicillin Scaffolds for Bone Defect Treatment: Cytocompatibility and Antibacterial Activity”, Journal of Sol-Gel Science and Technology, Vol. 86, pp. 83-93, 2018.
16. Ibsen, C. J. S., and Birkedal, H., “Pyrophosphate-Inhibition of Apatite Formation Studied by In Situ
X-Ray Diffraction”, Minerals, Vol. 8, p. 65, 2018.
17. Saiz, E., Gremillard, L., Menendez, G., Miranda, P., Gryn, K., and Tomsia, A. P., “Preparation of Porous Hydroxyapatite Scaffolds”, Materials Science and Engineering: C, Vol. 27, pp. 546-550, 2007.
18. Bohner, M., and Lemaitre, J., “Can Bioactivity be Tested In Vitro with SBF Solution?”, Biomaterials, Vol. 30 , pp. 2175-2179, 2009.
19. Nakhaee, F. M., Rajabi, M., and Bakhsheshi-Rad, H. R., “In-Vitro Assessment of β-Tricalcium Phosphate/Bredigite-Ciprofloxacin (CPFX) Scaffolds for Bone Treatment Applications”, Biomedical Materials, Vol. 16, p. 045038, 2021.
20. Hamvar, M., Bakhsheshi-Rad, H. R., Omidi, M., Fauzi Ismail, A., Aziz, M., Berto, F., and Chen, X., “Biocompatibility and Bioactivity of Hardystonite-Based Nanocomposite Scaffold for Tissue Engineering Applications”, Biomedical Physics & Engineering Express, Vol. 6, p. 035011, 2020.
21. Asghari, F., Samiei, M., Adibkia, Kh., Akbarzadeh, A., and Davaran, S., “Biodegradable and Biocompatible Polymers for Tissue Engineering Application: A Review”, Artificial Cells, Nanomedicine, and Biotechnology, Vol. 45, pp. 185-192, 2017.
22. Eilbagi, M., Emadi, R., Raeissi, K., Kharaziha, M., and Valiani, A., “Mechanical and Cytotoxicity Evaluation of Nanostructured Hydroxyapatite-Bredigite Scaffolds for Bone Regeneration”, Materials Science and Engineering C, Vol. 68, pp. 603-612, 2016.
23. Sadeghzade, S., Emadi, R., Tavangarian, F., and Naderi, M., “Fabrication and Evaluation of Silica-based Ceramic Scaffolds for Hard Tissue Engineering Applications”, Journal of Materials Science, Vol. 71, pp: 431-438, 2017.
24. Ochsner, A., and Ahmed, W., Biomechanics of Hard Tissues: Modeling, Testing, and Materials, John Wiley & Sons, 2011.
25. Liu, C., Zhang, J., Sun, J., Zhang, X., and Hu, Y., “Addition of Al-Ti-C Master Alloys and Diopside to Improve the Performance of Alumina Matrix Ceramic Materials”, Ceramics International, Vol. 33, pp. 1149-1154, 2007.
26. Kokubo, T., Kim, H. M., and Kawashita, M., “Novel Bioactive Materials with Different Mechanical Properties”, Biomaterials, Vol. 24, pp. 2161-2175, 2003.
27. Wu, Ch., Chang, J., Zhai. W., and Ni, S., “A Novel Bioactive Porous Bredigite (Ca7MgSi4O16) Scaffold with Biomimetic Apatite Layer for Bone Tissue Engineering”, Materials Science Materials in Medicine, Vol. 18, pp. 857-864, 2007.
28. Wu, Ch., and Chang, J., “Degradation, Bioactivity, and Cytocompatibility of Diopside, Akermanite, and Bredigite Ceramics”, Biomedical Material Research Part B: Application Biomaterials, Vol. 83, pp. 153-160, 2007.
29. Denry, I., and Kuhn, L. T., “Design and Characterization of Calcium Phosphate Ceramic Scaffolds for Bone Tissue Engineering”, Dental Materials, Vol. 32, pp.43-53, 2016.
Journal of Advanced Materials in Engineering (Esteghlal)
Volume 40, Issue 3
November 2021
Pages 79-97

Files

Share

How to cite

Statistics

ارتقاء امنیت وب با وف ایرانی