ساخت و ارزیابی زخم‌پوش هیدروژلی حاوی پلی‌وینیل الکل، کیتوسان، فلکس و ذرات روی برای ترمیم زخم‌های مزمن

نوع مقاله : مقاله پژوهشی

نویسندگان

1 گروه مهندسی مواد، دانشکده فنی و مهندسی گلپایگان، دانشگاه صنعتی اصفهان، گلپایگان، ایران

2 گروه علوم پایه، دانشکده فنی و مهندسی گلپایگان، دانشگاه صنعتی اصفهان، گلپایگان، ایران

چکیده

مقدمه و اهداف: این پژوهش با هدف ساخت و ارزیابی هیدروژل‌های پوشاننده زخم بر پایه پلی‌وینیل الکل، کیتوسان، عصاره فلکس و میکروذرات روی، به‌منظور بهبود خواص مکانیکی و زیستی انجام شده است.
مواد و روش‌ها: چهار گروه هیدروژلی با مقادیر مختلف میکروذرات روی (0، 2، 5 و 10 درصد وزنی)، تهیه شدند. ساختار هیدروژل‌ها با استفاده از پراش پرتو ایکس و میکروسکوپ الکترونی روبشی بررسی شد. همچنین، خواص مکانیکی شامل استحکام کششی و ازدیاد طول تا شکست، اندازه‌گیری شد. به‌علاوه، آزمون‌های زیست‌تخریب‌پذیری و جذب آب برای ارزیابی عملکرد زیستی هیدروژل انجام گرفت.
یافته‌ها: بررسی فازی نشان داد که با افزایش درصد روی، ساختار هیدروژل‌ها از حالت آمورف به نیمه‌بلوری تغییر یافت. تصاویر میکروسکوپی، توزیع یکنواخت ذرات روی را در ساختار هیدروژلی تأیید کردند. آزمون‌های مکانیکی نشان دادند که نمونه‌های دارای 2 و 5 درصد روی بهترین عملکرد را داشتند، به‌طوری‌که استحکام کششی آن‌ها به‌ترتیب 20 و 12/8 مگاپاسکال و ازدیاد طول آن‌ها 24/3 و 2/5 درصد بود. درمقابل، تجمع ذرات روی در نمونه حاوی 10 درصد باعث کاهش این خواص شد. در آزمون زیست‌تخریب‌پذیری، نمونه دارای 5 درصد روی پس از 30 روز، حدود 45 درصد از وزن خود را حفظ کرد، درحالی‌که نمونه بدون روی کاملاً تخریب شد. همچنین، نمونه‌های دارای 2 و 5 درصد روی، بیشترین ظرفیت جذب آب را به‌ترتیب حدود 780 و 800 درصد نشان دادند.
نتیجه‌گیری: هیدروژل‌های بهینه‌شده با ترکیب مناسب میکروذرات روی و مواد زیست‌فعال، خواص مکانیکی و زیستی بهتری از خود نشان دادند و به‌عنوان گزینه‌ای کارآمد برای درمان زخم‌های مزمن پیشنهاد می‌شوند.

کلیدواژه‌ها

موضوعات

عنوان مقاله [English]

Preparation and Evaluation of Hydrogel Wound Dressings Containing Polyvinyl Alcohol, Chitosan, Flax, and Zinc Particles for Chronic Wound Healing

نویسندگان [English]

  • Azam Rastegar 1
  • Narges Johari 1
  • Maryam Zare 2
1 Materials Engineering group, Golpayegan College of Engineering, Isfahan University of Technology, Golpayegan, Iran
2 Basic Sciences Group, Golpayegan College of Engineering, Isfahan University of Technology, Golpayegan, Iran
چکیده [English]

Introduction and Objectives: This study aims to develop and evaluate hydrogel wound dressings based on polyvinyl alcohol, chitosan, flax extract, and zinc microparticles to enhance mechanical and biological properties.
Materials and Methods: Four groups of hydrogels containing different concentrations of zinc microparticles (0, 2, 5, and 10 wt. %) were fabricated. The structural properties were examined using X-ray diffraction (XRD) and scanning electron microscopy (SEM). The mechanical properties, including tensile strength and elongation at break, were assessed. Additionally, biodegradability and water absorption tests were conducted to evaluate the hydrogel's biological performance.
Results: Phase analysis indicated a transition from an amorphous to a semi-crystalline structure with increasing zinc microparticle concentration. Microscopic images confirmed the uniform distribution of zinc particles within the hydrogel matrix. Mechanical testing revealed that hydrogels with 2% and 5% zinc exhibited optimal properties, achieving tensile strengths of 20 MPa and 12.8 MPa and elongations of 24.3% and 2.5%, respectively. However, aggregation of zinc particles at 10% concentration reduced mechanical performance. Biodegradability tests showed that after 30 days, the hydrogel containing 5% zinc retained about 45% of its weight, whereas the zinc-free sample was fully degraded. Additionally, water absorption capacity improved, with 2% and 5% zinc-containing hydrogels achieving maximum absorption levels of approximately 780% and 800%, respectively.
Conclusion: The optimized hydrogel wound dressings, incorporating zinc microparticles and bioactive materials, demonstrated enhanced mechanical and biological properties, making them a promising candidate for chronic wound treatment.

کلیدواژه‌ها [English]

  • Zinc
  • Flax
  • Chitosan
  • Poly vinyl alcohol
  • Wound dressing

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مواد پیشرفته در مهندسی
دوره 44، شماره 4
(شماره پیاپی 51)
1404
صفحه 74-91

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