تولید و مشخصه‌یابی کلسیم منیزیم سیلیکات نانو متخلخل و بررسی اثر دمای کلسیناسیون بر رفتار دارورسانی آن

نویسندگان

دانشگاه آزاد اسلامی واحد نجف آباد

چکیده

در این پژوهش، سنتز کلسیم منیزیم سیلیکات نانو‌ متخلخل به‌منظور بهبود خواص دارورسانی و رهایش دارو انجام و مورد مطالعه قرار گرفت. این سنتز توسط پیش ماده تترااتیل اورتوسیلیکات (TEOS) و فعال کننده سطحی ستیل تری‌متیل آمونیوم برومید (CTAB) در محیط بازی به روش سل- ژل انجام شده است و ترکیب تولید شده در دماهای 600 و 800 درجه سانتی‌گراد مورد عملیات حرارتی قرار گرفت. هدف از این پژوهش بررسی اثر دمای کلسیناسیون بر پتانسیل بارگذاری و رهایش داروی ایبوپروفن توسط ترکیب تولیدی است. محصول به‌دست آمده توسط روش‌های پراش پرتو ایکس (XRD)، جذب- واجذب نیتروژن، طیف‌سنجی فروسرخ (FTIR)، طیف‌سنجی فرابنفش (UV)، میکروسکوپی الکترونی عبوری (TEM) و میکروسکوپی الکترونی روبشی گسیل میدانی (FE-SEM) مورد مطالعه قرار گرفت. نتایج آزمون جذب- واجذب نیتروژن حاکی از مساحت سطحی در گستره 42 تا 140 مترمربع بر گرم است. رهایش دارو پس از 240 ساعت نشان داد که نمونه کلسینه شده در دمای 600 درجه سانتی‌گراد رهایش کندتری داشته است که دلیل آن اندازه کوچک‌تر حفرات و مساحت سطحی بیشتر نسبت به نمونه دیگر است. همچنین عناصر کلسیم و منیزیم باعث افزایش قابلیت بارگذاری و ایجاد بستر مناسب جهت رهایش آرام‌تر دارو شده است. این پژوهش نشان داد که کلسیم منیزیم سیلیکات نانو متخلخل قابلیت بارگذاری و رهایش داروی ایبوپروفن را داراست و می‌تواند به‌عنوان یک سامانه نوین دارورسانی در حوزه مهندسی بافت استخوان مورد استفاده قرار گیرد.
 

کلیدواژه‌ها

عنوان مقاله [English]

Synthesis and Characterization of Nanoporous Calcium Magnesium Silicate and Assessment of the Calcination Temperature Effect on Its Drug Delivery Behavior

نویسندگان [English]

  • S. Ghadiri
  • A. Hassanzadeh-Tabrizi
Najafabad Branch, Islamic Azad University Najafabad
چکیده [English]

In this study, the synthesis of nano-porous calcium magnesium silicate was performed and studied to improve drug properties and drug release. This synthesis was carried out by using the tetraethyl ortho silicate precursor (TEOS) and the Cetyltrimethyl ammonium bromide surfactant (CTAB) in a sol-gel alkaline environment; and the product was heat treated at 600° C and 800° C temperatures. The purpose of this study is to investigate the effect of the calcination temperature on the potential for ibuprofen release by the production produced compound. The product was studied using X-ray diffraction patterns (XRD), Nitrogen adsorption / desorption, Fourier-transform infrared spectroscopy (FTIR), ultraviolet spectroscopy (UV) and Transmission electron microscopy (TEM), and field emission scanning electron microscopy (FE-SEM). The results of Nitrogen absorption-desorption assay showed a surface area of 42-140 m2 /g The drug release after 240 hours showed that the calcite sample had a lower release at 600 ° C, temperature that which was is due to the smaller size of the cavities and the more surface area, as compared tothan the other specimens. Also, calcium and magnesium elements increased  the loading capacity, and createcreating a suitable substrate for for the slower drug release. Overall, This this study showed that nano-porous magnesium silicate calcium has had  the ability to load and release the ibuprofen and can could be, therefore, used as a modern drug delivery system in the bone tissue engineering field.
 

کلیدواژه‌ها [English]

  • Calcium magnesium silicate
  • Controlled release
  • CTAB surfactant
  • Calcination temperature
  • Ibupropen

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مواد پیشرفته در مهندسی
دوره 37، شماره 1
خرداد 1397
صفحه 69-82

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