تأثیر عنصر مس بر نرخ تخریب و خواص بیولوژیکی آلیاژ منیزیم- آلومینیوم- مس ساخته شده به‌روش پلاسمای جرقه ای

نویسندگان

1 1. دانشکده مهندسی مواد، دانشگاه صنعتی اصفهان

2 2. دانشکده مهندسی کشاورزی، دانشگاه صنعتی اصفهان

چکیده

هدف از انجام این پژوهش، ساخت آلیاژهای Mg-Al-Cu حاوی مقادیر مختلف مس (0، 25/0، 5/0 و 1 درصد وزنی) به‌کمک روش تف­جوشی جرقه ­ای و ارزیابی نرخ تخریب و خواص بیولوژیکی آنها است. نتایج نشان داد که با افزودن 25/0 درصد مس نرخ تخریب از 039/0 سانتی‌متر بر ساعت در منیزیم خالص به 0058/0 سانتی­متر بر ساعت کاهش یافت. به‌علاوه درصد زیست‌پذیری سلول‌های MG63 در تماس با آلیاژ Mg-1Al-0.25Cu به‌طور قابل توجهی بالاتر (25/1 برابر) از آن در تماس با منیزیم خالص بود که به‌دلیل نرخ مناسب رهایش یون عناصر بود. همچنین، آلیاژ Mg-1Al-0.25Cu مس رفتار ضدباکتریایی قابل توجهی از خود نشان داد. بنابراین آلیاژ Mg-1Al-0.25Cu با نرخ تخریب مناسب، زیست­ سازگاری مطلوب و خواص ضدباکتریایی می ­تواند به عنوان کاشتنی­ ارتوپدی زیست‌تخریب ­پذیر معرفی شود.

کلیدواژه‌ها

عنوان مقاله [English]

Influence of Cu Element on Degradation Rate and Biological Properties of Mg-Al-Cu Alloy Prepared by Spark Plasma Sintering

نویسندگان [English]

  • N. Safari 1
  • M. Kharaziha 1
  • M. Toroghinejad 1
  • M. Kharaziha 1
  • V. Saeedi 2
1 1. Department of Materials Engineering, Isfahan University of Technology, Isfahan, Iran.
2 2. Department of Agricultural Engineering, Isfahan University of Technology, Isfahan, Iran.
چکیده [English]

The aim of this study was to fabricate the Mg-1Al-Cu alloys with various amounts of Cu content (0, 0.25, 0.5 and 1 wt.%) using spark plasma sintering (SPS) approach and evaluation of their degradation rate and biological properties. The results indicated that Cu incorporation (0.25 wt.%) significantly diminish degradation rate from 0.039 cm/h in pure Mg to 0.00584 cm/h in Mg-1Al-0.25Cu alloy. In addition, Mg-1Al-0.25Cu alloy could noticeably (1.25 times) promote viability of MG63 cells compared to pure Mg, owing to the optimized ion release. Moreover, the antibacterial activity of Mg-1Al-0.25Cu was considerable. In summary, Mg-1Al-0.25Cu alloy with appropriate degradation rate, good biocompatibility and antibacterial properties can be introduced as a biodegradable orthopedic implant.

کلیدواژه‌ها [English]

  • Magnesium alloy
  • Degradation rate
  • Cytotoxicity
  • Antibacterial Properties

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مواد پیشرفته در مهندسی
دوره 38، شماره 3
آذر 1398
صفحه 87-99

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