جذب داروی فلوکونازول در ایروژل سیلیس به‌روش غوطه‌وری و بررسی سرعت و مکانیزم رهایش دارو

نویسندگان

دانشکده مهندسی نساجی، دانشگاه صنعتی اصفهان

چکیده

در این پژوهش، ایروژل ­های سیلیس آب­دوست و آب­گریز به‌روش سل- ژل دو مرحل ه­ای و خشک‌کردن در دمای محیط سنتز شدند و بارگذاری داروی فلوکونازول در آنها به‌روش غوطه ­وری ذرات ایروژل حاصل در محلول یک درصد دارو در اتانول بدون نیاز به استفاده از شرایط فوق­ بحرانی با موفقیت انجام شد. مشخص شد که بیشترین مقدار بارگذاری دارو در ایروژل آب­دوست و آب­گریز در مدت زمان 24 ساعت غوطه‌­وری حاصل شده که به‌­ترتیب برابر 92/1 و 98/1 درصد است. خواص فیزیکی ایروژل­ های سنتز شده توسط آزمون جذب و واجذب نیتروژن بررسی شد. حضور دارو در ساختار ایروژل با استفاده از آزمون طیف­ سنجی مادون قرمز با تبدیل فوریه تأیید شد. نتایج نشان داد که ساختار ایروژل سنتز­شده دارای تخلخل بالای 80 درصد، قطر حفرات 6-8 نانومتر و مساحت سطح در حدود 800-100 مترمربع بر گرم است. میزان رهایش دارو با استفاده از دستگاه طیف ­سنج ارزیابی شد و مشخص شد که سرعت رهایش فلوکونازول در ایروژل سیلیس آب­دوست از نمونه آب­گریز بیشتر است. همچنین مشاهده شد که رهایش دارو در هر دو نمونه ایروژل آب­دوست و آب‌گریز از سازوکار فیکی پیروی می­کند.

کلیدواژه‌ها


عنوان مقاله [English]

Adsorption of Fluconazole Drug on Silica Aerogel‌ by Immersion Method and Investigation of the Rate and Mechanism of Drug Release

نویسندگان [English]

  • M. Afrashi
  • D. Semnani
  • Z. Talebi
Department of Textile Engineering, Isfahan University of Technology, Isfahan, Iran.
چکیده [English]

In this study, adsorption of fluconazole on silica aerogel was performed successfully by the immersion method in the 1% solution of fluconazole-ethanol at the ambient condition and without using the supercritical method. The hydrophobic and hydrophilic silica aerogels were synthesized by the two-stage sol-gel method and dried at the ambient temperature. This method had most of drug loading at 24 h. It was 1.92% and 1.98% for the hydrophilic and hydrophobic silica aerogels, respectively. Physical properties of the synthesized aerogels were studied by the nitrogen absorption and desorption tests. The presence of fluconazole and the chemical structure of the samples were determined by fourier-transform infrared spectroscopy (FTIR). As well, the loading and release of the drug were investigated using a spectrophotometer. The results showed the structure of the synthesized aerogels had a pore diameter of 6-8 nm and a surface area of about 800-100 m2/g. The study of the drug release also revealed that the release rate of fluconazole in the hydrophilic silica aerogel was higher than that of the hydrophobic sample.

کلیدواژه‌ها [English]

  • silica aerogel
  • Sol-gel
  • Drug delivery
  • Fluconazole
  • Drug loading
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