ارزیابی تأثیر میزان اکسید روی و مورفولوژی داربست‌‌های نانوکامپوزیتی پلی‌کاپرولاکتون/ نانوذرات اکسید روی بر خواص مکانیکی این داربست‌‌ها

نویسندگان

گروه مهندسی مواد، دانشکده فنی و مهندسی گلپایگان، دانشگاه صنعتی اصفهان، گلپایگان، 8771767948، ایران

چکیده

ویژگی‌‌های مکانیکی و ساختاری داربست‌‌های مهندسی بافت یکی از عوامل مهم در بازسازی و ترمیم بافت محسوب می‌‌شوند. از این‌رو، در پژوهش حاضر، به بررسی تأثیر میزان نانوذرات اکسید روی و مورفولوژی داربست بر خواص مکانیکی داربست‌های نانوکامپوزیتی پلی‌کاپرولاکتون/ نانوذرات اکسید روی پرداخته شد. در این پژوهش، داربست‌های نانوکامپوزیتی پلی‌کاپرولاکتون/ نانوذرات اکسید روی به روش ریخته‌گری حلال/ شستشوی ذرات نمک و با سه غلظت متفاوت 0، 5 و 15 درصد وزنی نانوذرات اکسید روی تهیه شدند. سپس، از روش پراش پرتو ایکس (XRD) به‌منظور تأیید فازهای مطلوب در ترکیب داربست استفاده شد. استحکام فشاری داربست‌‌های ساخته شده نیز به‌عنوان شاخصی از خواص مکانیکی، ارزیابی شد. همچنین، به‌منظور بررسی مورفولوژی و تخلخل داربست‌‌ها و توزیع نانوذرات اکسید روی در داربست از میکروسکوپ الکترونی روبشی (SEM) استفاده شد. نتایج به‌دست آمده نشان داد که با افزودن نانوذرات اکسید روی به‌عنوان تقویت‌کننده، استحکام فشاری داربست‌‌ها افزایش می‌‌یابد. از سوی دیگر، با افزایش نانوذرات اکسید روی به بیش از 5 درصد وزنی، استحکام فشاری کاهش یافت. در واقع، داربست نانوکامپوزیتی پلی‌کاپرولاکتون/ اکسید روی با 5 درصد وزنی اکسید روی بیشترین میزان استحکام و مدول فشاری و یکپارچگی ساختار را داشت. 

کلیدواژه‌ها


عنوان مقاله [English]

INVESTIGATION OF THE INFLUENCE OF ZINC OXID CONTENT AND SCAFFOLD MORPHOLOGY ON THE MECHANICAL PROPERTIES OF POLY(ε-CAPROLACTONE) / ZINC OXIDE NANOCAMPOSITE SCAFFOLDS

نویسندگان [English]

  • F. Rafati
  • N. Johari
  • F. Zohari
Materials Engineering Group, Golpayegan College of Engineering, Isfahan University of Technology
چکیده [English]

In the present study, PCL/ZnO nanocomposite scaffolds containing 0, 5, and 15 wt.% of ZnO nanoparticles were prepared via the salt leaching/solvent casting method. The influence of ZnO nanoparticles on the morphology of prepared PCL/ZnO scaffolds was investigated using SEM images. The compressive strength test evaluated the effect of scaffolds’ morphology on mechanical properties. The XRD technique confirmed the desired phases in the scaffold composition. The results showed that the compressive strength and structural integrity of the scaffolds increased by increasing ZnO nanoparticles content as the reinforcement. However, the compressive strength and structural integrity decreased by increasing the amount of ZnO nanoparticles up to more than 5 wt.%. In summary, PCL/ZnO nanocomposite scaffold containing 5 wt.% of ZnO nanoparticles revealed the highest strength, compressive modulus, and structural integrity.

کلیدواژه‌ها [English]

  • Poly(ε-caprolactone)/zinc oxide
  • morphology
  • mechanical properties
1. Kanitakis, J., "Anatomy, Histology and Immunohistochemistry of Normal Human Skin", European Journal of Dermatology, Vol. 12, No. 4, pp 390-401, 2002.
2. Debels, H., Hamdi, M., Abberton, K., and Morrison, W., "Dermal Matrices and Bioengineered Skin Substitutes: A Critical Review of Current Options", Plastic Reconstructive Surgery Global Open, Vol. 3, No. 1, pp 1-6, 2015
3. Ma, P.X., Elisseeff, J., Scaffolding in Tissue Engineering, CRC press, 2005.
4. Drury, J.L., and Mooney, D.J., "Hydrogels for Tissue Engineering: Scaffold Design Variables and Applications", Biomaterials, Vol. 24, No. 24, pp 4337-4351, 2003.
5. Liu, C., Xia, Z., Czernuszka, J., "Design and Development of Three-dimensional Scaffolds for Tissue Engineering", Chemical Engineering Research Design, Vol. 85, No. 7, pp 1051-1064, 2007.
6. Sumner, D., and Heseltine, J., "Tip Vortex Structure for A Circular Cylinder with A Free End", Journal of Wind Engineering and Industrial Aerodynamics, Vol. 96, No. 6-7, pp 1185-1196, 2008.
7. Adaramola, M., Akinlade, O., Sumner, D., Bergstrom, D., and Schenstead, A. "Turbulent Wake Of A Finite Circular Cylinder of Small Aspect Ratio", Journal of Fluids and Structures, Vol. 22, No. 6-7, pp 919-928, 2006.
8. Lemos, E.M., Patrício, P.S., and Pereira, M.M., "3D Nanocomposite Chitosan/Bioactive Glass Scaffolds Obtained Using Two Different Routes: An Evaluation of the Porous Structure and Mechanical Properties", Química Nova, Vol. 39, pp 462-466, 2016.
9. Gaharwar, A.K., Rivera, C.P., Wu, C.J., and Schmidt, G., "Transparent, Elastomeric and Tough Hydrogels From Poly (Ethylene Glycol) and Silicate Nanoparticles", Acta Biomaterialia, Vol. 7, No. 12, pp 4139-4148, 2011.
10. Rezwan, K., Chen, Q., Blaker, J.J., and Boccaccini, A.R., "Biodegradable and Bioactive Porous Polymer/Inorganic Composite Scaffolds for Bone Tissue Engineering", Biomaterials, Vol. 27, No. 18, pp 3413-3431, 2006.
11. Depan, D., Girase, B., Shah, J., and Misra, R., "Structure–Process–Property Relationship of the Polar Graphene Oxide-Mediated Cellular Response and Stimulated Growth of Osteoblasts on Hybrid Chitosan Network Structure Nanocomposite Scaffolds", Acta Biomaterialia, Vol. 7, No. 9, pp 3432-3445, 2011.
12. Hu, X., Jia, X., Zhi, C., Jin, Z., and Miao, M., "Improving the Properties of Starch-Based Antimicrobial Composite Films Using Zno-Chitosan Nanoparticles", Carbohydrate Polymers, Vol. 210, pp 204-209, 2019.
13. Puppi, D., Chiellini, F., Piras, A.M., and Chiellini, E., "Polymeric Materials for Bone and Cartilage Repair", Progress in Polymer Science, Vol. 35, No. 4, pp 403-440, 2010.
14. Dillow, A., and Lowman, A., Biomimetic Materials and Design: Biointerfacial Strategies, Tissue Engineering and Targeted Drug Delivery, CRC Press, 2002.
15. Shalumon, K., Anulekha, K., Chennazhi, K.P., Tamura, H., Nair, S., and Jayakumar, R., "Fabrication of Chitosan/Poly (Caprolactone) Nanofibrous Scaffold for Bone and Skin Tissue Engineering", International Journal of Biological Macromolecules, Vol. 48, No. 4, pp 571-576, 2011.
16. Okada, M., "Chemical Syntheses of Biodegradable Polymers", Progress in Polymer Science, Vol. 27, No. 1, pp 87-133, 2002.
17. Woodruff, M.A., and Hutmacher, D.W., "The Return of a Forgotten Polymer—Polycaprolactone in the 21st Century", Progress in Polymer Science, Vol. 35, No. 10, pp 1217-1256, 2010.
18. Zare, E., Pourseyedi, S., Khatami, M., and Darezereshki, E., "Simple Biosynthesis of Zinc Oxide Nanoparticles Using Nature's Source, And It's in Vitro Bio-Activity", Journal of Molecular Structure, Vol. 1146, pp 96-103, 2017.
19. Ahmed, S., Chaudhry, S.A., and Ikram, S., "A Review on Biogenic Synthesis of ZnO Nanoparticles Using Plant Extracts and Microbes: A Prospect Towards Green Chemistry", Journal of Photochemistry Photobiology B: Biology, Vol. 166, pp 272-284, 2017.
20. Ågren, M.S., Studies on Zinc in Wound Healing, 1990.
21. Manuja, A., Raguvaran, R., Kuma,r B., Kalia, A., and Tripathi, B., "Accelerated Healing of Full Thickness Excised Skin Wound in Rabbits Using Single Application of Alginate/Acacia Based Nanocomposites of ZnO Nanoparticles", International Journal of Biological Macromolecules, Vol. 155, pp 823-833, 2020.
22. Johari, N., Zohari, F., and Rafati, F., "Evaluation of the Morphologies and Formation Mechanisms of ZnO and CuO Nanoparticles Synthesized via the Co-precipitation Method", Metallurgical and Materials Engineering, Vol. 40, No. 1, pp 50-56, 2021.
23. Ansari, Z., Kalantar, M., Kharaziha, M., Ambrosio, L., and Raucci, M.G., "Polycaprolactone/Fluoride Substituted-hydroxyapatite (PCL/FHA) Nanocomposite Coatings Prepared by In-situ Sol-gel Process for Dental Implant Applications", Progress in Organic Coatings, Vol. 147, pp 105873, 2020.
24. Khatiwala, V.K., Shekhar, N., Aggarwal, S., and Mandal, U., "Biodegradation of Poly (ε-caprolactone)(PCL) Film by Alcaligenes Faecalis", Journal of Polymers and the Environment, Vol. 16, No. 1, pp 61-67, 2008.
25. Lamas, M.L., Lima, M.S., Pinho, A.C., Tugushi, D., Katsarava, R., Costa, E.C., Correia, I.J., Serra, A.C., Coelho, J.F., and Fonseca, A.C., "Towards the Development of Electrospun Mats from Poly (ε-caprolactone)/Poly (ester amide) s Miscible Blends", Polymer, Vol. 150, pp 343-359, 2018.
26. Wang, L., Wu, Y., Chen, F., and Yang, X., "Photocatalytic Enhancement of Mg-doped ZnO Nanocrystals Hybridized with Reduced Graphene Oxide Sheets", Progress in Natural Science: Materials International, Vol. 24, No. 1, pp 6-12, 2014.
27. Ghassemieh, E., "Morphology and Compression Behaviour of Biodegradable Scaffolds Produced by the Sintering Process", Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine, Vol. 222, No. 8, pp 1247-1262, 2008.
28. Diba, M., Kharaziha, M., Fathi, M., Gholipourmalekabadi, M., Samadikuchaksaraei, A., "Preparation and Characterization of Polycaprolactone/Forsterite Nanocomposite Porous Scaffolds Designed for Bone Tissue Regeneration", Composites Science Technology, Vol. 72, No. 6, pp 716-723, 2012.

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